Semaglutide vs. Tirzepatide for Weight Loss
How the two most-requested metabolic peptides compare on results, cost, and side effects.
By The Editorial Team·Medically reviewed by Dr. Alana Reyes, MD (Board-certified, Internal Medicine)·9 min read
Semaglutide and tirzepatide are the two most-requested medications at medical weight-loss clinics. This article compares mechanism, typical results, cost, and tolerability.
The short version
Both are effective; tirzepatide's dual mechanism may produce greater average weight loss, while semaglutide has a longer real-world track record.